Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy

2008172 citationsJournal Articlegold Open Access

Authors

Jean-Michel Ubeda · Wilfrid Laurier University

Danielle Légaré · Université Laval

Frédéric Raymond · Université Laval

Amin Ahmed Ouameur · Wilfrid Laurier University

Sébastien Boisvert · Université Laval

Philippe Rigault · Université Laval

Jacques Corbeil ·

Abstract

Aneuploidy has been suggested as an important cause of drug resistance in several organisms and additional studies should reveal the potential importance of this phenomenon in drug resistance in Leishmania.

Topics & Keywords

Research on Leishmaniasis Studies Trypanosoma species research and implications

Publication Details

Published in: Genome biology

Volume 9, Issue 7, pp. R115-R115

DOI: 10.1186/gb-2008-9-7-r115

Field-Weighted Citation Impact: 7.60

Command Palette

Modulation of gene expression in drug resistant Leishmania is associated with gene amplification, gene deletion and chromosome aneuploidy

Authors

Abstract

Topics & Keywords

Publication Details