Population Pharmacokinetics of Intravenous Polymyxin B in Critically Ill Patients: Implications for Selection of Dosage Regimens

2013418 citationsJournal Article

Authors

Ana Maria Sandri · Pontifícia Universidade Católica do Rio Grande do Sul

Cornelia B. Landersdorfer · University at Buffalo, State University of New York

Jovan Jacob · Monash University

Márcio Manozzo Boniatti · Hospital de Clínicas de Porto Alegre

Micheline Gisele Dalarosa · Hospital Nossa Senhora da Conceição

Diego R. Falci · Hospital Nossa Senhora da Conceição

Tainá F. Behle

Abstract

Our study showed that doses of intravenous polymyxin B are best scaled by total body weight. Importantly, dosage selection of this drug should not be based on renal function.

Topics & Keywords

Antibiotic Resistance in Bacteria Antibiotics Pharmacokinetics and Efficacy Pneumocystis jirovecii pneumonia detection and treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Infectious Diseases

Volume 57, Issue 4, pp. 524-531

DOI: 10.1093/cid/cit334

Field-Weighted Citation Impact: 10.71