Detection in Fecal DNA of Colon Cancer–Specific Methylation of the Nonexpressed Vimentin Gene

2005368 citationsJournal Articlebronze Open Access

Authors

Wei-Dong Chen · Howard Hughes Medical Institute

Zhifen Han · Howard Hughes Medical Institute

Joel Skoletsky · University Hospitals of Cleveland

Jeff Olson · University Hospitals of Cleveland

Jerome F. Sah · Howard Hughes Medical Institute

Lois L. Myeroff · Howard Hughes Medical Institute

Petra Platzer

Abstract

Aberrant methylation of exon-1 sequences within the nontranscribed vimentin gene is a novel molecular biomarker of colon cancer and can be successfully detected in fecal DNA to identify nearly half of individuals with colon cancer.

Topics & Keywords

Epigenetics and DNA Methylation Cancer-related gene regulation Genetic factors in colorectal cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 97, Issue 15, pp. 1124-1132

DOI: 10.1093/jnci/dji204

Field-Weighted Citation Impact: 6.52