The Prognostic Role of a Gene Signature from Tumorigenic Breast-Cancer Cells

2007988 citationsJournal Articlebronze Open Access

Authors

Rui Liu · University of Michigan–Ann Arbor

Xinhao Wang

Grace Chen · University of Michigan–Ann Arbor

Piero Dalerba · University of Michigan–Ann Arbor

Austin Gurney

Timothy Hoey

Gavin Sherlock · Stanford University

John Lewicki

Kerby Shedden

Abstract

The IGS is strongly associated with metastasis-free survival and overall survival for four different types of tumors. This genetic signature of tumorigenic breast-cancer cells was even more strongly associated with clinical outcomes when combined with the WR signature in breast cancer.

Topics & Keywords

Cancer Cells and Metastasis Breast Cancer Treatment Studies Cancer-related Molecular Pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 356, Issue 3, pp. 217-226

DOI: 10.1056/nejmoa063994

Field-Weighted Citation Impact: 55.08