Hesperidin as a preventive resistance agent in MCF–7 breast cancer cells line resistance to doxorubicin

201481 citationsJournal Articlediamond Open Access

Authors

Rifki Febriansah · Muhammadiyah University of Yogyakarta

Dewi P.P. Dyaningtyas · Universitas Gadjah Mada

Sarmoko Sarmoko · Jenderal Soedirman University

Nunuk Aries Nurulita · Muhammadiyah University Purwokerto

Edy Meiyanto · Universitas Gadjah Mada

Agung Endro Nugroho · Universitas Gadjah Mada

Abstract

Hesperidin has cytotoxic effect on MCF-7/Dox cells with IC50 of 11 µmol/L. Hesperidin did not increased the apoptotic induction combined with doxorubicin. Co-chemotherapy application of doxorubicin and hesperidin on MCF-7/Dox cells showed synergism effect through inhibition of Pgp expression.

Topics & Keywords

Bioactive Compounds and Antitumor Agents Cancer Treatment and Pharmacology Cancer therapeutics and mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Asian Pacific Journal of Tropical Biomedicine

Volume 4, Issue 3, pp. 228-233

DOI: 10.1016/s2221-1691(14)60236-7

Field-Weighted Citation Impact: 2.17