<i>syn</i>‐ and Enantioselective Henry Reactions of Aliphatic Aldehydes and Application to the Synthesis of Safingol

Atom-economic synthesis: The syn- and highly enantioselective Henry reactions of aliphatic aldehydes catalyzed by a readily available β-amino alcohol copper catalyst were developed and successfully utilized in the synthesis of safingol. The ligand could be easily recovered without any racemization (see scheme).