Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype

20051,875 citationsJournal Articlebronze Open Access

Authors

Brunangelo Falini · University of Perugia

Cristina Mecucci · University of Perugia

Enrico Tiacci · University of Perugia

Myriam Alcalay · European Institute of Oncology

Roberto Rosati · University of Perugia

Laura Pasqualucci · Columbia University

Roberta La Starza ·

Abstract

Cytoplasmic NPM is a characteristic feature of a large subgroup of patients with AML who have a normal karyotype, NPM gene mutations, and responsiveness to induction chemotherapy.

Topics & Keywords

Acute Myeloid Leukemia Research Retinoids in leukemia and cellular processes Nuclear Structure and Function

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 352, Issue 3, pp. 254-266

DOI: 10.1056/nejmoa041974

Field-Weighted Citation Impact: 43.69