Functionalized Carbon Nanotubes for Plasmid DNA Gene Delivery

20041,087 citationsJournal Article

Authors

Davide Pantarotto · Centre National de la Recherche Scientifique

Ravi Singh · University of London

David McCarthy · University of London

Mathieu Erhardt · Institut de Biologie Moléculaire des Plantes

Jean‐Paul Briand · Institut de Biologie Moléculaire et Cellulaire

Maurizio Prato · University of Trieste

Kostas Kostarelos

Abstract

Genetic vaccination and gene therapy research could benefit from the application of carbon nanotubes. Functionalized, positively charged, water-soluble carbon nanotubes are able to penetrate into cells (see figure) and can transport plasmid DNA by formation of noncovalent DNA–nanotube complexes. Such nanotubes can be used as novel nonviral delivery systems for gene transfer.

Topics & Keywords

RNA Interference and Gene Delivery Advanced biosensing and bioanalysis techniques Graphene and Nanomaterials Applications

Publication Details

Published in: Angewandte Chemie International Edition

Volume 43, Issue 39, pp. 5242-5246

DOI: 10.1002/anie.200460437

Field-Weighted Citation Impact: 15.56

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Functionalized Carbon Nanotubes for Plasmid DNA Gene Delivery

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Abstract

Topics & Keywords

Publication Details