Adenosine triphosphate-magnesium dichloride during hyperdynamic porcine endotoxemia: Effects on hepatosplanchnic oxygen exchange and metabolism*

During long-term hyperdynamic porcine endotoxemia, ATP-MgCl2 normalized the otherwise progressive rise of the ileal mucosal-arterial Delta PCO2. Furthermore, it allowed blunting of the continuous decrease in hepatic lactate clearance, thus preserving the metabolic coupling between lactate release from the intestine and lactate utilization by the liver.