Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain

2010381 citationsJournal Article

Authors

Martin Münzel · Center for Integrated Protein Science Munich

Daniel Globisch · Center for Integrated Protein Science Munich

Tobias Brückl · Ludwig-Maximilians-Universität München

Mirko Wagner · Center for Integrated Protein Science Munich

Veronika Welzmiller · Ludwig-Maximilians-Universität München

Stylianos Michalakis · Center for Integrated Protein Science Munich

Markus Müller

Abstract

Mind over matter: LC-MS has allowed the amount of the post-replicatively formed DNA base 5-hydroxymethylcytosine (see picture; left) to be quantified in brain tissue. The nucleoside is most abundant in areas that are associated with higher cognitive functions, and its content in mouse hippocampi seems to increase with age. The new method enables hydroxymethylcytosine to be quantified with unprecedented accuracy.

Topics & Keywords

Epigenetics and DNA Methylation HIV Research and Treatment Amino Acid Enzymes and Metabolism

Publication Details

Published in: Angewandte Chemie International Edition

Volume 49, Issue 31, pp. 5375-5377

DOI: 10.1002/anie.201002033

Field-Weighted Citation Impact: 16.46

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Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain

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Abstract

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Publication Details