The ever-evolving landscape of candidaemia in patients with acute leukaemia: non-susceptibility to caspofungin and multidrug resistance are associated with increased mortality

201580 citationsJournal Articlebronze Open Access

Authors

Emily Wang · The University of Texas MD Anderson Cancer Center

Dimitrios Farmakiotis · The University of Texas MD Anderson Cancer Center

Daisy Yang · The University of Texas MD Anderson Cancer Center

Deborah McCue · The University of Texas MD Anderson Cancer Center

Hagop M. Kantarjian · The University of Texas MD Anderson Cancer Center

Dimitrios P. Kontoyiannis · The University of Texas MD Anderson Cancer Center

Abstract

In patients with acute leukaemia, a shift in candidaemia epidemiology was noted with a 99% predominance of non-albicans species. Non-susceptibility of Candida strains to caspofungin or multidrug resistance were independent markers of poor outcome in this patient population.

Topics & Keywords

Antifungal resistance and susceptibility Fungal Infections and Studies Neutropenia and Cancer Infections

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Antimicrobial Chemotherapy

Volume 70, Issue 8, pp. 2362-2368

DOI: 10.1093/jac/dkv087

Field-Weighted Citation Impact: 7.75