INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to Atherosclerosis

2009246 citationsJournal Articlegold Open Access

Authors

Yàn Liú · University of North Carolina at Chapel Hill

Hanna K. Sanoff · UNC Lineberger Comprehensive Cancer Center

Hyunsoon Cho · University of North Carolina at Chapel Hill

Christin E. Burd · University of North Carolina at Chapel Hill

Chad Torrice · University of North Carolina at Chapel Hill

Karen L. Mohlke · University of North Carolina at Chapel Hill

Joseph G. Ibrahim

Abstract

Genotypes of rs10757278 linked to increased risk of atherosclerotic diseases are also associated with decreased expression in PBTL of the INK4/ARF locus, which encodes three related anti-proliferative transcripts of known importance in tumor suppression and aging.

Topics & Keywords

Atherosclerosis and Cardiovascular Diseases RNA modifications and cancer Genetic Associations and Epidemiology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 4, Issue 4, pp. e5027-e5027

DOI: 10.1371/journal.pone.0005027

Field-Weighted Citation Impact: 10.90