Circulating Tumor Cells in Patients with Breast Cancer Dormancy

2004969 citationsJournal Articlebronze Open Access

Authors

Songdong Meng

Debasish Tripathy · Susan G. Komen Breast Cancer Foundation

Eugene P. Frenkel · Susan G. Komen Breast Cancer Foundation

Sanjay Shete · The University of Texas MD Anderson Cancer Center

Elizabeth Z. Naftalis · The University of Texas Southwestern Medical Center

James F. Huth · The University of Texas Southwestern Medical Center

Peter D. Beitsch

Abstract

The CTCs that are dying must be replenished every few hours by replicating tumor cells somewhere in the tissues. Hence, there appears to be a balance between tumor replication and cell death for as long as 22 years in dormancy candidates. We conclude that this is one mechanism underlying tumor dormancy.

Topics & Keywords

Cancer Cells and Metastasis Metastasis and carcinoma case studies Cancer, Stress, Anesthesia, and Immune Response

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 10, Issue 24, pp. 8152-8162

DOI: 10.1158/1078-0432.ccr-04-1110

Field-Weighted Citation Impact: 9.28