Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects the Heart Against Energy Stress

2014563 citationsJournal Articlebronze Open Access

Authors

Yoshiyuki Ikeda · Kyushu University Hospital

Akihiro Shirakabe · Istituto Neurologico Mediterraneo

Yasuhiro Maejima · Istituto Neurologico Mediterraneo

Peiyong Zhai · Kyushu University Hospital

Sebastiano Sciarretta · Istituto Neurologico Mediterraneo

Jessica Toli · Istituto Neurologico Mediterraneo

Masatoshi Nomura

Abstract

Disruption of Drp1 induces mitochondrial elongation, inhibits mitochondrial autophagy, and causes mitochondrial dysfunction, thereby promoting cardiac dysfunction and increased susceptibility to ischemia/reperfusion.

Topics & Keywords

Mitochondrial Function and Pathology Autophagy in Disease and Therapy ATP Synthase and ATPases Research

UN Sustainable Development Goals

Affordable and clean energy

Publication Details

Published in: Circulation Research

Volume 116, Issue 2, pp. 264-278

DOI: 10.1161/circresaha.116.303356

Field-Weighted Citation Impact: 16.51