Meta-analysis Confirms CR1, CLU, and PICALM as Alzheimer Disease Risk Loci and Reveals Interactions With APOE Genotypes

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Authors

Abstract

We confirm in a completely independent data set that CR1, CLU, and PICALM are AD susceptibility loci in European ancestry populations. Genotypes at PICALM confer risk predominantly in APOE ε4-positive subjects. Thus, APOE and PICALM synergistically interact.

Topics & Keywords

Alzheimer's disease research and treatments Genetic Associations and Epidemiology Amyloidosis: Diagnosis, Treatment, Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Archives of Neurology

Volume 67, Issue 12, pp. 1473-1473

DOI: 10.1001/archneurol.2010.201

Field-Weighted Citation Impact: 22.73