Histone Deacetylase 3 Antagonizes Aspirin-Stimulated Endothelial Nitric Oxide Production by Reversing Aspirin-Induced Lysine Acetylation of Endothelial Nitric Oxide Synthase

2010103 citationsJournal Articlegreen Open Access

Authors

Saet-Byel Jung · Chungnam National University

Cuk‐Seong Kim · Chungnam National University

Asma Naqvi · Chungnam National University

Tohru Yamamori · Chungnam National University

Ilwola Mattagajasingh · Chungnam National University

Timothy A. Hoffman · Chungnam National University

Marsha P. Cole

Abstract

Lysine acetylation of eNOS is a posttranslational protein modification supporting low-dose aspirin-induced vasoprotection. HDAC3, by deacetylating aspirin-acetylated eNOS, antagonizes aspirin-stimulated endothelial production of NO.

Topics & Keywords

Histone Deacetylase Inhibitors Research Synthesis and Catalytic Reactions Adenosine and Purinergic Signaling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 107, Issue 7, pp. 877-887

DOI: 10.1161/circresaha.110.222968

Field-Weighted Citation Impact: 2.03