Hippocampal hyperactivation in presymptomatic familial Alzheimer's disease

2010248 citationsJournal Article

Authors

Yakeel T. Quiroz · Universidad de Antioquia

Andrew E. Budson · Edith Nourse Rogers Memorial Veterans Hospital

Kim Celone · Boston University

Adriana Ruiz · Universidad de Antioquia

Randall E. Newmark · Boston University

Gabriel Castrillón · Instituto Tecnológico Metropolitano

Francisco Lopera

Abstract

Our results demonstrate that functional changes within the hippocampal memory system occur years before cognitive decline in FAD. These presymptomatic changes in hippocampal physiology in FAD suggest that hippocampal fMRI patterns during associative encoding may also provide a preclinical biomarker in sporadic AD.

Topics & Keywords

Alzheimer's disease research and treatments Dementia and Cognitive Impairment Research Memory and Neural Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Neurology

Volume 68, Issue 6, pp. 865-875

DOI: 10.1002/ana.22105

Field-Weighted Citation Impact: 5.81