Vascular Endothelial Growth Factor

20091,271 citationsReview

Authors

Napoleone Ferrara · Bechtel (United States)

Abstract

Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration. This brief review provides a historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis.

Topics & Keywords

Angiogenesis and VEGF in Cancer Cancer, Hypoxia, and Metabolism Vascular Tumors and Angiosarcomas

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arteriosclerosis Thrombosis and Vascular Biology

Volume 29, Issue 6, pp. 789-791

DOI: 10.1161/atvbaha.108.179663

Field-Weighted Citation Impact: 45.54