ALK Rearrangements Are Mutually Exclusive with Mutations in EGFR or KRAS: An Analysis of 1,683 Patients with Non–Small Cell Lung Cancer

2013599 citationsJournal Articlebronze Open Access

Authors

Justin F. Gainor · Memorial Sloan Kettering Cancer Center

Anna M. Varghese · University of California, Irvine

Sai‐Hong Ignatius Ou · Massachusetts General Hospital

Sheheryar Kabraji · University of California, Irvine

Mark M. Awad · Memorial Sloan Kettering Cancer Center

Ryohei Katayama · Memorial Sloan Kettering Cancer Center

Amanda C. Pawlak

Abstract

Functional ALK rearrangements were mutually exclusive with EGFR and KRAS mutations in a large Western patient population. This lack of overlap was also observed in ALK-positive cancers with acquired resistance to crizotinib.

Topics & Keywords

Lung Cancer Treatments and Mutations Lung Cancer Research Studies Colorectal Cancer Treatments and Studies

Publication Details

Published in: Clinical Cancer Research

Volume 19, Issue 15, pp. 4273-4281

DOI: 10.1158/1078-0432.ccr-13-0318

Field-Weighted Citation Impact: 41.35

Command Palette

<i>ALK</i> Rearrangements Are Mutually Exclusive with Mutations in <i>EGFR</i> or <i>KRAS</i>: An Analysis of 1,683 Patients with Non–Small Cell Lung Cancer

Authors

Abstract

Topics & Keywords

Publication Details