Lifetime Risk of Melanoma in CDKN2A Mutation Carriers in a Population-Based Sample

2005209 citationsJournal Articlebronze Open Access

Authors

Colin B. Begg · University of California, Irvine

Irene Orlow · University of Tasmania

Amanda Hummer · University of New Mexico

Bruce K. Armstrong · University of Michigan–Ann Arbor

Anne Kricker · University of Pennsylvania

Loraine D. Marrett · University of Tasmania

Robert C. Millikan

Abstract

CDKN2A mutation carriers in the general population have a much lower risk of melanoma than that suggested by estimates obtained from multiple-case families. The preponderance of familial clustering of melanoma occurs in families without identifiable mutations in CDKN2A.

Topics & Keywords

BRCA gene mutations in cancer Cancer Genomics and Diagnostics Cutaneous Melanoma Detection and Management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 97, Issue 20, pp. 1507-1515

DOI: 10.1093/jnci/dji312

Field-Weighted Citation Impact: 8.30