Genetic Variations at Loci Involved in the Immune Response Are Risk Factors for Hepatocellular Carcinoma

2010154 citationsJournal Articlehybrid Open Access

Authors

Robert Clifford · National Cancer Institute

Jinghui Zhang · National Cancer Institute

Daoud Meerzaman · National Cancer Institute

Myung-Soo Lyu · National Cancer Institute

Ying Hu · National Cancer Institute

Constance M. Cultraro · National Cancer Institute

Richard P. Finney

Abstract

Combined analysis of CNV, individual SNPs, and pathways suggest that HCC susceptibility is mediated by germline factors affecting the immune response and differences in T-cell receptor processing.

Topics & Keywords

Viral-associated cancers and disorders Glycosylation and Glycoproteins Research Lymphoma Diagnosis and Treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Hepatology

Volume 52, Issue 6, pp. 2034-2043

DOI: 10.1002/hep.23943

Field-Weighted Citation Impact: 6.97