PDL1 Regulation by p53 via miR-34

2015665 citationsJournal Articlebronze Open Access

Authors

María Angélica Cortez · The Ohio State University

Cristina Ivan · Mirna Therapeutics (United States)

David R. Valdecanas · The University of Texas MD Anderson Cancer Center

Xiaohong Wang · The Ohio State University

Heidi J. Peltier · Mirna Therapeutics (United States)

Yuping Ye · The Ohio State University

Luiz H. Araujo

Abstract

We identified a novel mechanism by which tumor immune evasion is regulated by p53/miR-34/PDL1 axis. Our results suggest that delivery of miRNAs with standard therapies, such as XRT, may represent a novel therapeutic approach for lung cancer.

Topics & Keywords

MicroRNA in disease regulation RNA modifications and cancer Cancer-related Molecular Pathways

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 108, Issue 1

DOI: 10.1093/jnci/djv303

Field-Weighted Citation Impact: 15.83