Cryptococcal Antigen Screening in Patients Initiating ART in South Africa: A Prospective Cohort Study

2015119 citationsJournal Articlehybrid Open Access

Authors

Nicky Longley · St George's, University of London

Joseph N Jarvis · University of Pennsylvania

Graeme Meintjes · University of Cape Town

Andrew Boulle · Western Cape Department of Health

Anna Cross · Desmond Tutu HIV Foundation

Nicola Kelly · Desmond Tutu HIV Foundation

Nelesh P. Govender

Abstract

CrAg screening of individuals initiating ART and preemptive fluconazole treatment of CrAg-positive patients resulted in markedly fewer cases of CM compared with historic unscreened cohorts. Studies are needed to refine management of CrAg-positive patients who have high mortality that does not appear to be wholly attributable to cryptococcal disease.

Topics & Keywords

Fungal Infections and Studies Antifungal resistance and susceptibility Pneumocystis jirovecii pneumonia detection and treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Infectious Diseases

Volume 62, Issue 5, pp. 581-587

DOI: 10.1093/cid/civ936

Field-Weighted Citation Impact: 9.38