A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition

2015576 citationsJournal Articlebronze Open Access

Authors

Milena Perez Mak · The University of Texas MD Anderson Cancer Center

Pan Tong · The University of Texas MD Anderson Cancer Center

Lixia Diao · The University of Texas MD Anderson Cancer Center

Robert J. Cardnell · The University of Texas MD Anderson Cancer Center

Don L. Gibbons · The University of Texas MD Anderson Cancer Center

William N. William · The University of Texas MD Anderson Cancer Center

Abstract

This new signature provides a novel, patient-based, histology-independent tool for the investigation of EMT and offers insights into potential novel therapeutic targets for mesenchymal tumors, independent of cancer type, including immune checkpoints.

Topics & Keywords

Cancer Cells and Metastasis Cancer Immunotherapy and Biomarkers Epigenetics and DNA Methylation

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 22, Issue 3, pp. 609-620

DOI: 10.1158/1078-0432.ccr-15-0876

Field-Weighted Citation Impact: 10.35