Diagnostic and Prognostic Value of the Cerebrospinal Fluid Concentration of Immunoglobulin Free Light Chains in Clinically Isolated Syndrome with Conversion to Multiple Sclerosis

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Authors

Gleb Makshakov · City Clinical Hospital No 31

В. Д. Назаров · First Pavlov State Medical University of St. Petersburg

О. В. Кочетова · City Clinical Hospital No 31

Е. А. Суркова · First Pavlov State Medical University of St. Petersburg

С. В. Лапин · First Pavlov State Medical University of St. Petersburg

E. P. Evdoshenko · City Clinical Hospital No 31

Abstract

The concentration of CSF FLC predicts conversion to MS within 2 years following CIS. OCB-positive patients with an early conversion have a higher concentration of CSF-FLC. We have also shown a prognostic significance of k-FLCCSF for future EDSS-progression.

Topics & Keywords

Multiple Sclerosis Research Studies Systemic Lupus Erythematosus Research Peripheral Neuropathies and Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 10, Issue 11, pp. e0143375-e0143375

DOI: 10.1371/journal.pone.0143375

Field-Weighted Citation Impact: 3.77