The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

19891,687 citationsReview

Authors

Bruce Beutler · Howard Hughes Medical Institute

Abstract

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models and humans. Tex cells are characterized by progressive loss of effector functions, high and sustained inhibitory receptor expression, ...Read More

Topics & Keywords

Public Health and Nutrition

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annual Review of Immunology

Volume 7, Issue 1, pp. 625-655

DOI: 10.1146/annurev.iy.07.040189.003205

Field-Weighted Citation Impact: 164.47