Lysosomal alterations in peripheral blood mononuclear cells of Parkinson's disease patients

201568 citationsJournal Article

Authors

Nikolaos Papagiannakis · National and Kapodistrian University of Athens

Maria Xilouri · Academy of Athens

Christos Koros · National and Kapodistrian University of Athens

María Stamelou · National and Kapodistrian University of Athens

Roubina Antonelou · National and Kapodistrian University of Athens

Matina Maniati · Academy of Athens

Dimitra Papadimitriou

Abstract

Reduced heatshock cognate-70 levels are suggestive of an apparent systemic chaperone-mediated autophagy dysfunction irrespective of genetic background. Glucocerebrosidase activity may serve as a screening tool to identify glucocerebrosidase mutation carriers with PD.

Topics & Keywords

Lysosomal Storage Disorders Research Parkinson's Disease Mechanisms and Treatments Autophagy in Disease and Therapy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Movement Disorders

Volume 30, Issue 13, pp. 1830-1834

DOI: 10.1002/mds.26433

Field-Weighted Citation Impact: 2.45