Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

20151,115 citationsJournal Articlebronze Open Access

Authors

Priscilla K. Brastianos · Dana-Farber Cancer Institute

Scott L. Carter

Sandro Santagata · Harvard University

Daniel P. Cahill

Amaro Taylor‐Weiner

Robert T. Jones · Dana-Farber Cancer Institute

Eliezer M. Van Allen · Dana-Farber Cancer Institute

Michael S. Lawrence

Peleg Horowitz

Abstract

Decisions for individualized therapies in patients with brain metastasis are often made from primary-tumor biopsies. We demonstrate that clinically actionable alterations present in brain metastases are frequently not detected in primary biopsies, suggesting that sequencing of primary biopsies alone may miss a substantial number of opportunities for targeted therapy.

Topics & Keywords

Brain Metastases and Treatment Lung Cancer Treatments and Mutations Cancer Genomics and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Cancer Discovery

Volume 5, Issue 11, pp. 1164-1177

DOI: 10.1158/2159-8290.cd-15-0369

Field-Weighted Citation Impact: 63.49