Ligase Chain Reaction

The ability to detect low numbers of DNA target sequences has been greatly enhanced by the development of geometric amplification techniques, most of which employ enzymatic methods to replicate a target DNA or RNA sequence in an autocatalytic fashion. These techniques have become so widely used that a new journal, PCR Methods and Applications, has arisen in an attempt to consolidate literature relevant to polymerase chain reactions (PCR) (1) and other amplification technologies.