Decline in FEV1 related to genetic polymorphisms (+138insA/delA and Lys198Asn) of the endothelin-1 gene in COPD. A pilot study.

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The present data shows that ET-1 and its functional polymorphisms may be implicated in COPD phenotype and severity.

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Published in: PubMed

Volume 14, Issue 8, pp. 705-19

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