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Onehundred specimens ofhumanbodyfat, 50necropsy and50biopsy, werecollected in1964 fromasemi-rural area insouth-eastern England. Thespecimens wereanalysed bytwomethods and theconcentrations ofseven organo-chlorine insecticides weredetermined. Theresults ofthetwo analytical methods wereingoodagreement. Endrin andheptachlor epoxide werenotdetected in anyofthespecimens analysed forthese compounds. Theaverage concentrations oflindane, op'-DDT, andop'-DDE wereverysmall: 0-015 p.p.m., 003p.p.m., and0-02p.p.m. respectively. Theaverage concentration ofHEOD inthe100specimens offat(nosignificant difference inthe meansofthenecropsy andbiopsy fats wasdetected) was0-21p.p.m., asinthe1961survey. The average concentration oftotal equivalent-DDT (DDT+ DDE)inthe50necropsy fats was3-9 p.p.m., ascompared with2-2p.p.m. in1961. Inthebiopsy fats theaverage concentration formales was49p.p.m., andforfemales 3-4p.p.m. Onemethod wassuitable fortheseparate determination ofpp'-DDTandpp'-DDE. Theaverage concentration ofpp'-DDT was1-0p.p.m. inthe100 necropsy andbiopsy fats. Theaverage concentration ofpp'-DDE was2-2p.p.m. inthe50necropsy fats, and31p.p.m. and2-0p.p.m. inmaleandfemale biopsy fats respectively. Thevariability ofthe concentrations ofthese compounds inthenecropsy specimens wasgenerally greater thaninthe biopsy specimens. Nosignificant differences werefoundwhich wereattributable toageortothe cause ofdeath. Itisconsidered that theamountsfoundofthese compounds donotconstitute a hazard tothepopulation sampled inthis survey. Thedesign ofsurveys todetermine theconcentrations oforgano-chlorine insecticides inmanisdiscussed. Organo-chlorine insecticides maybeclassified, according totheir chemical composition, into three groups: (a)diphenylethane derivatives, e.g., pp'-DDT, pp'-DDE, Rhothane, Methoxychlor, etc.; (b) they-isomer ofhexachlorocyclohexane, andtoxaphene, achlorinated camphene; and(c) hexachloronorbornene derivatives, e.g., aldrin, dieldrin, endrin, heptachlor, etc.* Thevarious membersofthese groups ofcompounds possess varying propensities forstorage in thebodyfatofexperimental animals. Theuseof these insecticides inagriculture andpublic health,