MicroRNA-146a Induced by Hypoxia Promotes Chondrocyte Autophagy through Bcl-2

201569 citationsJournal Articlegold Open Access

Authors

Fei Zhang

Jing Wang · Second Military Medical University

Jianjun Chu · Hefei First People's Hospital

Cheng Yang · Second Military Medical University

Hui Xiao · Second Military Medical University

Chenglong Zhao · Second Military Medical University

Zhengwang Sun · Second Military Medical University

Abstract

HIF-1α, miR-146a and Bcl-2 play crucial roles during hypoxia-induced autophagy, Hypoxia, HIF-1α and miR-146a promote chondrocytes autophagy via depressing Bcl-2. We conclude that miR-146a may serve as a novel therapeutic target for protecting cartilage from degeneration in OA.

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Publication Details

Published in: Cellular Physiology and Biochemistry

Volume 37, Issue 4, pp. 1442-1453

DOI: 10.1159/000438513

Field-Weighted Citation Impact: 3.40

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MicroRNA-146a Induced by Hypoxia Promotes Chondrocyte Autophagy through Bcl-2

Authors

Abstract

Topics & Keywords

Publication Details