Silver(<scp>i</scp>)–N-heterocyclic carbene catalyzed multicomponent reactions: a facile synthesis of multisubstituted pyridines

201533 citationsJournal Article

Authors

Shravankumar Kankala · University of KwaZulu-Natal

Ramakanth Pagadala · Durban University of Technology

Suresh Maddila · University of KwaZulu-Natal

Chandra Sekhar Vasam · Telangana University

Sreekantha B. Jonnalagadda · Durban University of Technology

Abstract

A room temperature four component reaction between aromatic aldehydes, CH2(CN)2and NH4OAc with ketones mediated by Ag(<sc>i</sc>)–NHC pre-catalysts to produce multisubstituted pyridines in a short reaction time in eco-friendly ethanol was described.

Topics & Keywords

N-Heterocyclic Carbenes in Organic and Inorganic Chemistry Catalytic Cross-Coupling Reactions Multicomponent Synthesis of Heterocycles

UN Sustainable Development Goals

Responsible consumption and production

Publication Details

Published in: RSC Advances

Volume 5, Issue 127, pp. 105446-105452

DOI: 10.1039/c5ra16582b

Field-Weighted Citation Impact: 1.89