Non-random fragmentation patterns in circulating cell-free DNA reflect epigenetic regulation

2015223 citationsJournal Articlegold Open Access

Authors

Maxim Ivanov · Siberian Branch of the Russian Academy of Sciences

Ancha Baranova · Institute of Chemical Biology and Fundamental Medicine

Timothy Butler · Oregon Health & Science University

Paul T. Spellman · Oregon Health & Science University

Vladislav Mileyko · Siberian Branch of the Russian Academy of Sciences

Abstract

Experimental outcomes suggest that cfDNA retains characteristics previously noted in genome-wide analysis of chromatin structure, in particular, in MNase-seq assays. Thus far the analysis of the DNA fragmentation pattern may aid further developing of cfDNA based biomarkers for a variety of human conditions.

Topics & Keywords

Cancer Genomics and Diagnostics Epigenetics and DNA Methylation Genomics and Chromatin Dynamics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: BMC Genomics

Volume 16, Issue S13, pp. S1-S1

DOI: 10.1186/1471-2164-16-s13-s1

Field-Weighted Citation Impact: 2.34