A Semiautomated Method for Quantification of F 18 Florbetapir PET Images

201583 citationsJournal Articlebronze Open Access

Authors

Abhinay D. Joshi · scPharmaceuticals (United States)

Michael J. Pontecorvo · scPharmaceuticals (United States)

Ming‐Chi Lu · scPharmaceuticals (United States)

Daniel Skovronsky · scPharmaceuticals (United States)

Mark A. Mintun · scPharmaceuticals (United States)

Michael D. Devous · scPharmaceuticals (United States)

Abstract

This semiautomated F 18 Florbetapir PET quantification method yielded mcSUVrs that significantly correlated with measures of amyloid pathology at autopsy. The method also effectively discriminated autopsy-identified amyloid-positive and -negative cases using a whole-cerebellum mcSUVr threshold of 1.10.

Topics & Keywords

Alzheimer's disease research and treatments Dementia and Cognitive Impairment Research Medical Imaging Techniques and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Nuclear Medicine

Volume 56, Issue 11, pp. 1736-1741

DOI: 10.2967/jnumed.114.153494

Field-Weighted Citation Impact: 5.42