Animal Model of Sensorineural Hearing Loss Associated with Lassa Virus Infection

201585 citationsJournal Articlebronze Open Access

Authors

Nadezhda E. Yun · The University of Texas Medical Branch at Galveston

Shannon E. Ronca · The University of Texas Medical Branch at Galveston

Atsushi Tamura · The University of Texas Medical Branch at Galveston

Takaaki Koma · The University of Texas Medical Branch at Galveston

Alexey Seregin · The University of Texas Medical Branch at Galveston

Kelly T. Dineley · Metabiota (United States)

Abstract

Sensorineural hearing loss is a major complication for LF survivors. The development of a small-animal model of LASV infection that replicates hearing loss and the clinical and pathological features of LF will significantly increase knowledge of pathogenesis and vaccine studies. In addition, such a model will permit detailed characterization of the hearing loss mechanism and allow for the development of appropriate diagnostic approaches and medical care for LF patients with hearing impairment.

Topics & Keywords

Viral Infections and Outbreaks Research SARS-CoV-2 and COVID-19 Research Viral gastroenteritis research and epidemiology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Virology

Volume 90, Issue 6, pp. 2920-2927

DOI: 10.1128/jvi.02948-15

Field-Weighted Citation Impact: 1.75