Alpha‐synuclein in gastric and colonic mucosa in Parkinson's disease: Limited role as a biomarker

201584 citationsJournal Article

Authors

Sun Ju Chung · Asan Medical Center

Ju‐Yeon Kim · Asan Medical Center

Hyo Jeong Lee · Ulsan College

Ho‐Sung Ryu · Asan Medical Center

Kiju Kim · University of Ulsan

Jeong Hoon Lee · Asan Medical Center

Kee Wook Jung · Asan Medical Center

Abstract

The presence of alpha-synuclein immunoreactivity in gastric and colonic mucosa was detected in a similar manner in patients with PD, patients with MSA, and controls, thus suggesting a limited role of enteric mucosal alpha-synuclein as a diagnostic biomarker for PD. Future studies are warranted to detect pathological alpha-synuclein strains.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Restless Legs Syndrome Research Dysphagia Assessment and Management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Movement Disorders

Volume 31, Issue 2, pp. 241-249

DOI: 10.1002/mds.26473

Field-Weighted Citation Impact: 7.05