The domestic cat as a natural animal model of Alzheimer’s disease

201589 citationsJournal Articlegold Open Access

Authors

James Chambers · The University of Tokyo

Takahiko Tokuda · Kyoto Prefectural University of Medicine

Kazuyuki Uchida · The University of Tokyo

Ryotaro Ishii · Kyoto Prefectural University of Medicine

Harutsugu Tatebe · Kyoto Prefectural University of Medicine

Erika Takahashi · Azabu University

Takami Tomiyama

Abstract

These results suggest that Aβ oligomers are more important than SP for NFT formation and the subsequent neurodegeneration. The domestic cat is a unique animal species that naturally replicates various AD pathologies, especially Aβ oligomer accumulation, NFT formation, and neuronal loss.

Topics & Keywords

Alzheimer's disease research and treatments Tryptophan and brain disorders Amino Acid Enzymes and Metabolism

Publication Details

Published in: Acta Neuropathologica Communications

Volume 3, Issue 1, pp. 78-78

DOI: 10.1186/s40478-015-0258-3

Field-Weighted Citation Impact: 2.07

Command Palette

The domestic cat as a natural animal model of Alzheimer’s disease

Authors

Abstract

Topics & Keywords

Publication Details