Direct Evidence for Microdomain-Specific Localization and Remodeling of Functional L-Type Calcium Channels in Rat and Human Atrial Myocytes

201595 citationsJournal Articlehybrid Open Access

Authors

Alexey V. Glukhov · University of Verona

Marina Balycheva · Imperial College London

Jose L. Sanchez‐Alonso · University of Verona

Zeki Ilkan · Imperial College London

Anita Alvarez‐Laviada · University of Verona

Navneet Bhogal · Hammersmith Hospital

Ivan Diakonov ·

Abstract

We provide the first direct evidence for the existence of 2 distinct subpopulations of functional LTCCs in rat and human AMs, with their biophysical properties modulated in heart failure in a microdomain-specific manner.

Topics & Keywords

Cardiac electrophysiology and arrhythmias Ion channel regulation and function Neuroscience and Neural Engineering

Publication Details

Published in: Circulation

Volume 132, Issue 25, pp. 2372-2384

DOI: 10.1161/circulationaha.115.018131

Field-Weighted Citation Impact: 6.59

Command Palette

Direct Evidence for Microdomain-Specific Localization and Remodeling of Functional L-Type Calcium Channels in Rat and Human Atrial Myocytes

Authors

Abstract

Topics & Keywords

Publication Details