Изучение комбинированного действия циклофосфана и экстракта мицелия вешенки на меланому b16-f0 мышей, экспрессирующей зеленый флюоресцирующий белок

In this work we studied the combined action of cyclophosphamide and the extract of micellium of Pleurotus ostreatus on mice bearing melanoma B16-F0, expressing green fluorescent protein (GFP) in vivo. This model allows to recognize primary small-size tumors and metastases, unrecognizable by other methods. It was found that in case of combined administration of cyclophosphamide (300 mg/kg) and the extract of micellium of Pleurotus ostreatus (100 mg/kg), administered for 10 days after cyclophosphamide injection, the amount of leucocytes in peripheral blood of mice with melanoma B16-F0 reduced to 51 % of its initial value, while the administration of cyclophosphamide alone 27 %. It was shown that the administration of the extract of micellium of Pleurotus ostreatus leads to the inhibition of tumor growth about 61 %.