Inherited Mutations in Women With Ovarian Carcinoma

2015752 citationsJournal Articlebronze Open Access

Authors

Barbara M. Norquist · University of Washington

Maria I. Harrell · University of Washington

Mark F. Brady · Roswell Park Comprehensive Cancer Center

Tom Walsh · University of Washington Medical Center

Ming K. Lee · University of Washington Medical Center

Süleyman Gülsüner · University of Washington

Sarah S. Bernards

Abstract

Of 1915 patients with OC, 347 (18%) carried pathogenic germline mutations in genes associated with OC risk. PALB2 and BARD1 are suspected OC genes and together with established OC genes (BRCA1, BRCA2, BRIP1, RAD51C, RAD51D, MSH2, MLH1, PMS2, and MSH6) bring the total number of genes suspected to cause hereditary OC to 11.

Topics & Keywords

BRCA gene mutations in cancer Ovarian cancer diagnosis and treatment Cancer Genomics and Diagnostics

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA Oncology

Volume 2, Issue 4, pp. 482-482

DOI: 10.1001/jamaoncol.2015.5495

Field-Weighted Citation Impact: 41.25