Proton pump inhibitors alter the composition of the gut microbiota

2015856 citationsJournal Articlehybrid Open Access

Authors

Matthew Jackson · King's College London

Julia K. Goodrich · Cornell University

Maria-Emanuela Maxan · King's College Hospital NHS Foundation Trust

Daniel E. Freedberg · Columbia University Irving Medical Center

Julian A. Abrams · Columbia University Irving Medical Center

Angela C. Poole · Cornell University

Jessica L. Sutter

Abstract

Our findings describe a significant impact of PPIs on the gut microbiome and should caution over-use of PPIs, and warrant further investigation into the mechanisms and their clinical consequences.

Topics & Keywords

Gastroesophageal reflux and treatments Helicobacter pylori-related gastroenterology studies Gut microbiota and health

Publication Details

Published in: Gut

Volume 65, Issue 5, pp. 749-756

DOI: 10.1136/gutjnl-2015-310861

Field-Weighted Citation Impact: 38.85

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Proton pump inhibitors alter the composition of the gut microbiota

Authors

Abstract

Topics & Keywords

Publication Details