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Diabetes mellitus is a common disease, affecting millions of people in Europe and throughout the world. People suffering from chronic diseases like diabetes are ideal candidates for telemonitoring. In the last decade, technological progress in telemedicine has had a positive impact on health care management. It is now possible to provide telemetric services to a large number of patients using relatively simple telemetric applications. This chapter presents METABO system, focusing particularly on the context of its implementation, the user requirements, and problems faced and solved during the development process. The METABO system has been contrasted to the state of the art in telemedical diabetes management in order to underline its innovativeness. The main innovation is the ability to analyze and interpret the context-sensitive fusion of information from both body and environmental monitoring noninvasive devices and depict a complete framework of patient's status, enabling behavior prediction and consequent feedback generation.