Inhaled Methane Limits the Mitochondrial Electron Transport Chain Dysfunction during Experimental Liver Ischemia-Reperfusion Injury

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Authors

Gerda Strifler · University of Szeged

Eszter Tuboly · University of Szeged

Edit Szél · University of Szeged

Enikő Kaszonyi · University of Szeged

C.-M. Cao · University of Szeged

József Kaszaki · University of Szeged

András Mészáros ·

Abstract

The normoxic IR injury was accompanied by significant functional damage of the inner mitochondrial membrane, increased cytochrome c activity, enhanced ROS production and apoptosis. An elevated methane intake confers significant protection against mitochondrial dysfunction and reduces the oxidative damage of the hepatocytes.

Topics & Keywords

Mitochondrial Function and Pathology Renal function and acid-base balance Heme Oxygenase-1 and Carbon Monoxide

Publication Details

Published in: PLoS ONE

Volume 11, Issue 1, pp. e0146363-e0146363

DOI: 10.1371/journal.pone.0146363

Field-Weighted Citation Impact: 3.73

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Inhaled Methane Limits the Mitochondrial Electron Transport Chain Dysfunction during Experimental Liver Ischemia-Reperfusion Injury

Authors

Abstract

Topics & Keywords

Publication Details