Cereals' Products With Red Grape And Walnut Extracts As Functional Foods For Prevention Of Kidney Dysfunction

In the present research, two nutraceuticals made from<br> red grape and walnut that showed previously to improve kidney<br> dysfunction were incorporated separately into functional foods' bread<br> made from barley and rice bran. The functional foods were evaluated<br> in rats in which chronic renal failure was induced through feeding<br> diet rich in adenine and phosphate (APD). The evaluation based on<br> assessing kidney function, oxidative stress, inflammatory biomarkers<br> and body weight gain. Results showed induction of chronic kidney<br> failure reflected in significant increase in plasma urea, creatinine,<br> malondialdehyde, tumor necrosis factor- α and low density<br> lipoprotein cholesterol along with significant reduction of plasma<br> albumin, and total antioxidant and creatinine clearance and body<br> weight gain on feeding APD compared to control healthy group.<br> Feeding the functional foods produced amelioration in the different<br> biochemical parameters and body weight gain indicating<br> improvement in kidney function.