Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease

2016317 citationsJournal Articlegold Open Access

Authors

Amanda Heslegrave · University College London

Wendy Heywood · University College London

Ross W. Paterson · University College London

Nadia Magdalinou · UK Dementia Research Institute

Johan Svensson · University of Gothenburg

Per Johansson · Skaraborg Hospital

Annika Öhrfelt ·

Abstract

CSF concentrations of sTREM2 are higher in AD than in controls, and correlate with markers of neurodegeneration. CSF sTREM2 may be used to quantify glial activation in AD.

Topics & Keywords

Inflammation biomarkers and pathways Neuroinflammation and Neurodegeneration Mechanisms Medicinal Plants and Bioactive Compounds

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Molecular Neurodegeneration

Volume 11, Issue 1, pp. 3-3

DOI: 10.1186/s13024-016-0071-x

Field-Weighted Citation Impact: 14.95