IDH mutation and MGMT promoter methylation in glioblastoma: results of a prospective registry

2015160 citationsJournal Articlediamond Open Access

Authors

Pei Yang · Beijing Institute of Neurosurgery

Wei Zhang · Beijing Institute of Neurosurgery

Yinyan Wang · Beijing Institute of Neurosurgery

Xiaoxia Peng · Capital Medical University

Baoshi Chen · Capital Medical University

Xiaoguang Qiu · Beijing Tian Tan Hospital

Guilin Li ·

Abstract

Our study demonstrates IDH mutation and MGMT promoter methylation status independently associate with favorable outcome in TMZ+RT treated glioblastoma patients. However, these biomarkers differentially impact clinical TMZ response.

Topics & Keywords

Glioma Diagnosis and Treatment Brain Metastases and Treatment Meningioma and schwannoma management

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Oncotarget

Volume 6, Issue 38, pp. 40896-40906

DOI: 10.18632/oncotarget.5683

Field-Weighted Citation Impact: 6.75