Diabody Pretargeting with Click Chemistry In Vivo

201579 citationsJournal Articlebronze Open Access

Authors

Sander M. J. van Duijnhoven · Tagworks Pharmaceuticals (Netherlands)

Raffaella Rossin · Philips (Netherlands)

Sandra M. van den Bosch · NXP (Netherlands)

Michael Wheatcroft

Peter J. Hudson

Marc S. Robillard · Tagworks Pharmaceuticals (Netherlands)

Abstract

Pretargeting provides an alternative radioimmunotherapy and nuclear imaging strategy by overcoming the high renal retention of low-molecular-weight radiometal tumor-homing agents through the separate administration of a tumor-homing agent and a radioactive probe with fast clearance.

Topics & Keywords

Click Chemistry and Applications Monoclonal and Polyclonal Antibodies Research Radiopharmaceutical Chemistry and Applications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Nuclear Medicine

Volume 56, Issue 9, pp. 1422-1428

DOI: 10.2967/jnumed.115.159145

Field-Weighted Citation Impact: 4.11