Cytokines and Postoperative Delirium in Older Patients Undergoing Major Elective Surgery

2015175 citationsJournal Articlebronze Open Access

Authors

Sarinnapha M. Vasunilashorn · Harvard University

Long Ngo · Harvard University

Sharon K. Inouye · Harvard University

Towia A. Libermann · Harvard University

Richard N. Jones · Brown University

David C. Alsop · Beth Israel Deaconess Medical Center

Jamey Guess

Abstract

In this large, well-characterized cohort assessed at multiple timepoints, we observed an inflammatory signature of delirium involving elevated interleukin-6 at POD2, which may be an important disease marker for delirium. We also observed preliminary evidence for involvement of other cytokines.

Topics & Keywords

Intensive Care Unit Cognitive Disorders Anesthesia and Neurotoxicity Research Anesthesia and Sedative Agents

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journals of Gerontology Series A

Volume 70, Issue 10, pp. 1289-1295

DOI: 10.1093/gerona/glv083

Field-Weighted Citation Impact: 7.13