Mechanisms of Action of Liraglutide in Patients With Type 2 Diabetes Treated With High-Dose Insulin

201669 citationsJournal Articlebronze Open Access

Authors

Anna Vanderheiden · The University of Texas Southwestern Medical Center

Lindsay Harrison · Texas Diabetes & Endocrinology

Jeremy Warshauer · The University of Texas Southwestern Medical Center

Beverley Adams‐Huet · The University of Texas Southwestern Medical Center

Xilong Li

Qing Yuan · The University of Texas Southwestern Medical Center

Keith Hulsey · The University of Texas Southwestern Medical Center

Abstract

Treatment with liraglutide significantly improved insulin secretion, even in patients with long-standing T2D requiring high-dose insulin treatment. Liraglutide also decreased liver and sc fat, but it did not alter glucagon secretion.

Topics & Keywords

Diabetes Treatment and Management Diabetes Management and Research Metabolism, Diabetes, and Cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Journal of Clinical Endocrinology & Metabolism

Volume 101, Issue 4, pp. 1798-1806

DOI: 10.1210/jc.2015-3906

Field-Weighted Citation Impact: 2.20